At regular intervals during the study the rats were weighed and blood was taken for laboratory tests. The highest doses were equal to a human consuming 5,000 tablets of 200 micrograms chromium Picolinate. This study looked at various supplemental doses (including none) of chromium chloride and chromium Picolinate fed to rats for 6 months. Department of Agriculture was presented at the Society of Toxicology's annual meeting. On March 14, 1996, a safety study conducted by the U.S. In terms of the number of 200 mcg tablets, this would be 175,000 tablets per day for a human. For example, cats fed 1,000 mg of trivalent chromium per day showed no signs of toxicity (the equivalent daily dose for a 150 lb person would be approximately 35,000 mg per day or 3.5 million mcg per day. It is extremely difficult to poison laboratory animals with oral chromium. However, diabetics considering the use of chromium picolinate supplements should have their blood sugar level carefully monitored, because of chromium's role as an insulin helper. Both acute and chronic toxicity tests of chromium picolinate have established that it is completely non toxic at nutritional levels. Many studies in human and other animals show that chromium picolinate is very effective but more importantly extremely safe. The results showed that exercise training combined with chromium nicotinate supplementation resulted in significant weight loss and lowered the insulin response to an oral glucose load. In a 1997 study done at the University of Texas at Austin, researchers examined the effects of 400 mcg of chromium and exercise training on young, obese women. After 26 weeks, chromium picolinate-supplemented patients showed increased lean body mass whereas the other treatment groups still had reduced lean body mass.1 During the 26-week treatment period, subjects received either placebo or 200 mcg chromium yeast or 200 mcg chromium picolinate in a double-blind manner. Researchers involved in a 1997 study assessed the effects of chromium yeast and chromium picolinate on lean body mass in 36 obese patients during and after weight reduction with a very low calorie diet. Because of these reports, chromium picolinate supplements have become very popular. Limited research suggests that moderate increases in chromium, in the form of chromium picolinate, may cause weight loss, reduce fat and increase muscle mass. It will be keeping its advice about chromium supplements under review and looking at evidence that emerges in the future. The Agency bases its advice on the balance of available scientific evidence. There is no need to avoid chromium picolinate. For those people who wish to supplement their diet with chromium, the maximum upper level recommended by the EVM is 10 mg a day. The FSA advises that most people can get the chromium they need from a healthy, balanced diet. On the basis of the results from this research, which COM received in November 2004, the Committee concluded that the balance of the evidence suggested that chromium picolinate was not genotoxic. The COM reviewed the genotoxicity of chromium and chromium picolinate and recommended some further research. In the light of this, the Food Standards Agency advised consumers who wished to take chromium supplements to use other types of chromium until specialist advice had been received from the Committee on Mutagenicity (COM). In 2003, the report of the Expert Group on Vitamins and Minerals (EVM) noted that there was some evidence suggesting that chromium picolinate might be genotoxic, which means that it could damage DNA.ĭamage to DNA can ultimately lead to cancer. It is no longer advising people to avoid this type of chromium. The Food Standards Agency has revised its advice on the safety of chromium picolinate supplements. I did some research and found the following articles: Obviously, its recommended that no supplement such as this is taken excessively. The last thing they need are rumours that it can cause cancer. Many users on this site obviously use Chromium in some form considering its one of the most popular supplements. I honestly think you need to substantiate such serious claims. Well documented that it can cause cancer at the cellular level?
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